aplicação de insulina em diabéticos.1 . *NPL: Protamina Neutra Lispro; ** NPA: Protamina Neutra Aspart; ***NPH: Protamina Neutra Fonte: A atividade da insulina lispro inicia-se aproximadamente 15 minutos após a . médico e leve a embalagem ou bula do medicamento, se possível. Ligue para. subcutaneously administered insulin lispro 8 units from a study in 12 patients with type 1 diabetes is Subcutaneous Insulin Lispro in Type 1 Diabetes Patients*.

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However, glucose solution must be given intravenously if glucagon is not available or if the patient fails to respond to glucagon. Insulin lispro maintains more rapid absorption and elimination when compared to soluble human insulin in patients with hepatic impairment. In some instances, this condition may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique.

Patients must be instructed to always check the insulin label before each injection to avoid accidental mix-ups between the two insulija strengths of Humalog as well as other insulin products.

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Date of first authorisation: This may constitute a risk in situations where these abilities are of special importance e. Within muscle tissue this includes increasing glycogen, fatty acid, glycerol and protein synthesis and amino acid uptake, while decreasing glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism and amino acid output.

Insulin lispro did not induce fertility impairment, embryotoxicity or teratogenicity in animal studies.

Hypoglycaemia may be associated with listlessness, confusion, palpitations, headache, sweating and vomiting. MedDRA system organ classes. Clinical trials in patients with type 1 and type 2 diabetes have demonstrated reduced postprandial hyperglycaemia with insulin lispro compared to soluble human insulin.

Patients should be advised to take precautions to avoid hypoglycaemia whilst driving. Humalog should not be used if it appears cloudy, thickened, or slightly coloured or if solid inzulina are visible.

This medicinal product contains less than 1 mmol sodium 23 mg per dose, i. Overdose can result causing severe hypoglycemia. Tabulated list of adverse reactions The following related adverse reactions bua clinical trials are listed below as MedDRA preferred term by system organ class and in order of decreasing incidence very common: Mild hypoglycaemic episodes will respond to oral administration of glucose or other sugar or saccharated products.

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Patients with diabetes who are breast-feeding may require adjustments in insulin dose, diet or both.


The duration of action of Humalog is dependent on dose, site of injection, blood supply, temperature, and physical activity. The glucodynamic response to insulin lispro is not affected by renal or hepatic function impairment.

Humalog takes effect rapidly and has a shorter duration of activity 2 to 5 hours given subcutaneously as compared with soluble insulin. Pens should not be used if any part looks broken or damaged. To bookmark a medicine you must sign up and log in. Show table of contents Hide table of contents 1. iinsulina

Each KwikPen delivers units in steps of 1 unit. Patients who fail to respond to glucagon must be given glucose solution intravenously.

Humalog 200 Units/ml KwikPen, solution for injection in pre-filled pen

Pioglitazone should be discontinued, if any deterioration in cardiac symptoms occurs. Transferring a patient to another type or brand of insulin should be done under strict medical supervision. Cases of cardiac failure have been reported when pioglitazone was used in combination with insulin, especially in patients with risk factors for development of cardiac heart failure. No specific frequency for hypoglycaemia is presented, since hypoglycaemia is a result of both the insulin dose and other factors e.

Insulin requirements may be reduced in patients with hepatic impairment due to reduced capacity for gluconeogenesis and reduced insulin breakdown; however, in patients with chronic hepatic impairment, an increase in insulin resistance may lead to increased insulin requirements.

Strengths Available for Humalog |

After injection, the site of injection should not be massaged. If the patient is comatose, glucagon should be administered intramuscularly or subcutaneously. To email a medicine you must sign up and log in. A consequence of the pharmacodynamics of rapid-acting insulin analogues is that if hypoglycaemia occurs, it may occur earlier after an injection when compared with soluble human insulin.

Each pre-filled pen contains units of insulin lispro in 3 ml solution. The Humalog solution should be clear and colourless. By continuing to browse the site you are agreeing to our policy on the use of cookies. It may cause a rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating. Before using the KwikPen the user manual included in the package leaflet must be read carefully. Needles are not included.

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This site uses cookies. If the combination is used, patients should be observed for signs and symptoms of heart failure, weight gain and oedema. The pre-filled pen should not be stored with the needle attached. The pharmacokinetics of insulin lispro reflect a compound that is rapidly absorbed, and achieves peak blood levels 30 to 70 minutes following subcutaneous injection.

Special populations Renal impairment Insulin requirements may be reduced in the presence of renal impairment. The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. Severe hypoglycaemia may lead to loss of consciousness, and in extreme cases, death. The use of dosages which are inadequate or discontinuation of treatment, especially in insulin-dependent diabetics, may lead to hyperglycaemia and diabetic ketoacidosis; conditions which are potentially lethal.

Humalog insulin lispro is used to treat type 1 insulin-dependent diabetes in adults. Date of revision of the text. This is particularly important in those who have reduced or absent awareness of the warning signs of hypoglycaemia or have frequent episodes of hypoglycaemia.

Active ingredient insulin lispro.

In bulla with type 2 diabetes on maximum doses of sulphonyl urea agents, studies have shown that the addition of insulin lispro significantly reduces HbA1c compared to sulphonyl urea alone. Reporting suspected adverse reactions after authorisation of the medicinal product is important. To prevent the possible transmission of disease, each pen must be used by one patient only, even if the needle is changed.

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